Ionic Surfactant–Coated Burkholderia Cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols
- Hyunjin Kim, Yoon Kyung Choi, Jusuk Lee, Eungyeong Lee, Jaiwook Park*, and Mahn–Joo Kim*, Angew. Chem. Int. Ed. 2011, 50, 10944-10948. ,

We have developed a highly active enzyme by coating Burkholderia cepacia lipase with an ionic surfactant for use in dynamic kinetic resolution (DKR). With this enzyme (ISCBCL), we have demonstrated three important things: the fastest DKR of 1-phenylethanol, the highly enantioselective DKR of a wide range of secondary alcohols (RCH(OH)Ar), and the switching of lipase enantioselectivity. The switchable lipase enantioselectivity depends on the shape of aliphatic chain (R), which allows the preparation of R or S enantiomers via DKR.