Bioreducible polymers for gene silencing and delivery
-Sejin Son, Ran Namgung, Jihoon Kim, Kaushik Singha, Won Jong Kim *

This Account discusses current research trends and recent progress in the disulfide chemistry enabling novel and versatile designs of reducible polymeric gene delivery systems. We present strategies for the introduction of disulfide bonds into polymers. These representative examples and their respective outcomes elaborate the benefit and efficiency of disulfides at the individual stages of gene delivery