BK21 SEMINAR: Prof. James J. Moon (University of Michigan, Ann Arbor, …2026. 7. 6. (Mon), 16:00
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댓글 0건 조회 87회 작성일 26-07-09 11:14본문
BK21 SEMINAR
♧ Speaker: Prof. James J. Moon (University of Michigan, Ann Arbor, USA)
♧ Date: 2026. 7. 6. (Mon), 16:00♧ Venue: Chemistry Bldg. Room #310
Engineering Strategies to Modulate the Immune System
Advancing immunotherapy necessitates novel strategies that enhance therapeutic efficacy while minimizing immune-related adverse events. Among emerging frontiers, the gut microbiota—a complex and dynamic microbial ecosystem predominantly residing in the colon—has garnered intense scientific interest. The gut microbiome plays a pivotal role in modulating host immunity, and its dysbiosis is associated with a spectrum of diseases, underscoring the urgent need for targeted interventions. Here, we present a new strategy to modulate the gut microbiota for improving cancer immunotherapy. We are developing new dietary fiber-based biomaterials for in situ modulation of the gut microbiome for augmenting local and systemic immune responses. Oral inulin-gel enriches beneficial taxa through microbial fermentation, boosting both local and systemic immune activation. In tumor-bearing mice, inulin-gel in combination with anti-PD-1 immune checkpoint blockade led to robust anti- tumor efficacy while mitigating immune-related adverse events. Our gut microbiome- modulation strategies are currently being evaluated in clinical trials. As our second research thrust, we are developing a novel systemic delivery system for STING (stimulator of interferon genes) agonists, a critical pathway for orchestrating immune responses against cancer. While local STING activation effectively converts "cold" tumors into immunologically "hot" tumors, systemic delivery has been hampered by toxicity challenges. To overcome these challenges, we are developing lipid-based nanoparticles containing manganese and STING agonists as a potent platform for cancer immunotherapy. These nanoparticles demonstrate robust anti-tumor efficacy across various preclinical cancer models with a favorable safety profile. Our biomaterial-based strategies may offer powerful and convenient approaches to regulate the immune system as potential therapies for cancer and other diseases.
Host: Prof. Won Jong Kim (T.279-2104)
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