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[13.07월]김원종 교수 연구실-Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide

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작성자 최고관리자 댓글 조회 작성일 13-07-17 09:07

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Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide
Hyunwoo Kim, Duhwan Lee, Jinhwan Kim, Tae-il Kim *, and Won Jong Kim*



In this work, we developed functionalized reduced graphene oxide (PEG-BPEIrGO) as a nanotemplate for photothermally triggered cytosolic drug delivery. PEG-BPEI-rGO/DOX complex was found to escape from endosomes after cellular uptake by photothermally induced endosomal disruption and the proton sponge effect, followed by GSH-induced DOX release into the cytosol. Finally, it was concluded that a greater cancer cell death efficacy was observed in PEG-BPEI-rGO/DOX complex-treated cells with NIR irradiation than those with no irradiation.

이번 연구 성과는 약물 전달 과정에서의 한계점 중의 하나였던 약물전달체의 엔도좀 탈출의 문제를 광열 자극에 의해 해결할 수 있음을 보임과 동시에 엔도좀 탈출 후 세포질 내 자극에 의해 효과적으로 방출되는 메커니즘을 규명함으로써 앞으로 다양한 약물 전달용 플렛폼 적용될 것으로 기대된다.

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