1957: Seoul National University (B.S. - Chemistry)

1965: University of North Carolina-Chapel Hill (Ph.D. Organic Chemistry)

1994.04 - 국민훈장 동백장 (대한민국 정부)

1996.10 - 이태규 학술상 (대한화학회)

1997.03 - 상허대상 (학술분야, 상허문화재단)

Bioorganic Chemistry

Medicinal Chemistry

Physical Organic Chemistry

Organic Chemistry

2004

Min Su Han, Dong Ju Oh, and Dong H. Kim. " Inhibiton of a-Chymotrypsin with Thiol-bearing Substrate Analogs in the Presence of Zinc Ion".Bioorg. Med. Chem. Lett. 2004, 14, 701-705.

Jung Dae Park and Dong H. Kim. "Sulfamide derivatives as transition state analogue inhibitors for carboxypeptidase A". Bioorg. Med. Chem. 2004, In Press.

Min Su Han, Sang Oh Jung, Mahn-Joo Kim, and Dong H. Kim "Fluorometric Assay Protocol for Protease-Catalyzed Transesterification Reactions in Organic Solvents". J. Org. Chem. 2004, In Press

2003

Han, M.; Kim, D. H.. "Readily Available Fluoresence Probes for Zinc Ion in Aqueous Solution of Neutral pH", Supramolecular Chem. 2003, 15, 59-64.

Han, M.; Kim, D. H.. "Visual Detection of AMP and Real-Time Monitoring of Cyclic Nucleotide Phosphodiesterase (PDE) Activity in Neutral Aqueous Solution. Chemosensor-Coupled Assay of PDE and PDE Inhibitors", Bioorg. Med. Chem. Lett. 2003, 13, 1079-1082.

Lee, H. S.; Park, J. D.; Kim, D. H.. "Convenient Synthesis of Optically Pure a-Mono and a,a-Disubstituted b-Amino Acids" Bull. Kor. Chem. Soc. 2003, 24, 467-472.

Kim, S. -J.; Kim, D. H.; Park, J.D.; Woo, J. -R.; Jin, Y. Ryu, S.E. "Origin of the Stereospecificity in Binding Hydroxamate of a- ans b-Phenylalanine Methylamide to Thermolysin Revealed by the X-ray Crystallographic Study", Bioorg. Med. Chem. 2003, 11, 2421-2426.

Kim, D. H..; Han, M . "Molecular Probe for Selective Detection of Thiols in Water of Neutral pH", Bioorg. Med. Chem. Lett. 2003, 13, 2543-2546.

Park, J. D.; Kim, D. H.. "Reversed Hydroxamate-bearing Zinc Protease Inhibitors Mimic High Energy Intermediate along the Enzyme-catalyzed Reaction Pathway", Bioorg. Med. Chem. Lett. 2003, 13, 3161-3166.

Jin, J. -Y.; Tian, G. R.; Kim, D. H.. "Optically Active 2-Benzyl-3-methanesulfinylpropanoic Acid:Synthesis and Evaluation as Inhibitors for Carboxypeptidase A", Bioorg. Med. Chem.2003, 11, 4377-4381.

Lee, H. S.; Kim, D. H.. "Synthesis and Evaluation of a,a-Disubstituted-3-mercaptopropanoic Acids as Inhibitors for Carboxypeptidase A and Implications with Respect to Enzyme Inhibitor Design", Bioorg. Med. Chem.2003, 11, 4685-4891.

2002

Park, J. D.;Kim, D. H."Cysteine Derivatives as Inhibitors for Carboxypeptidase A: Synthesis and Structure-Activity Relationships", J. Med. Chem. 2002, 45, 911-918.

Lee, M.; Kim, D. H.."Synthesis and Kinetic Evaluation of Racemic and Optically Active 2-Benxyl-2-methyl-3,4-epoxybutanoic Acid as Irreversible Inactivators for Carboxypeptidase A" Bioorg. Med. Chem. 2002, 10, 913-922.

Cho, J. H.; Kim, D. H..; Chung, S. J.; Ha, N.; Oh, B.; Choi, K. Y. "Insight into the Stereochemistry in the Inhibition of Carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: Binding Modes of an Enantiomeric Pair of the Inhibitor to Carboxypeptidase A" Bioorg. Med. Chem. 2002, 10, 2015-2022.

Lee, H. S.; Kim, D. H.. "Alpha-alkylcysteines as Inhibitors for Carboxypeptidase A. Sythnesis, Evaluation, and Implication for Inhibitor Design strategy" Bull. Kor. Chem. Soc. 2002, 23, 593-598.

Kim, D. H..; Park, J.; Chung, S. J.; Park, J. D.; Park, N.; Han, J. H. "Cleavage of b-lactone ring by serine protease. Mechanistic implications" Bioorg. Med. Chem. 2002, 10, 2553-2560.

Chin, J.; Chung, S.; Kim, D. H.. "Synergistic Effect between Metal Coordination and Hydrogen Bonding in Phosphate and Halide Recognition " J. Am. Chem. Soc. 2002, 124, 10948-10949.

Han, M.; Kim, D. H.. "Naked-Eye Detection of Phosphate Ions in Water at Physiological pH: A Remarkably Selective and Easy-To-Assemble Colorimetric Phosphate-Sensing Probe" Angew. Chem. Int. Ed. 2002, 41, 3809-3811.

Park, J. D.; Kim, D. H..; Kim, S. -J.; Woo, J. -R.; Ryu, S. E. "Sulfamide-Based Inhibitors for Carboxypeptidase A. Novel Type Transition State Analogue Inhibitors for Zinc Proteases", J. Med. Chem. 2002, 45, 5295-5302.

2001

Kim, D. H.; Mobashery, S. "Mechanism-Based Inhibition of Zinc Proteases", Curr. Med. Chem. 2001, 8, 959.

Chung S. J.; Kim, D. H. "N-(Hydroxyaminocarbonyl)phenylalanine: A Novel Class of Inhibitor for Carboxypeptidase A", Bioorg. Med. Chem. 2001, 9, 185.

Park, J. D.; Lee, K. J.; Kim, D. H. "A New Inhibitor Design Strategy for Carboxypeptidase A as Exemplified by N-(2-Chloroethyl)-N-methylphenylalanine", Bioorg. Med. Chem. 2001, 9, 237.

Han, M.; Kim, D. H. "Effect of Zinc Ion on the Inhibition of Carboxypeptidase A by Imidazole-Bearing Substrate Analogues", Bioorg. Med. Chem. Lett. 2001, 11, 1425.

Cho, J. H.; Kim, D. H.; Kim, D.; Lee, K. J.; Choi, K. Y. "The Role of Tyr248 Probed by Mutant Bovine Carboxypeptidase A: Insight into the Catalytic Mechanism of Carboxypeptidase A", Biochemistry 2001, 40, 10197.

Park, J.; Tian, G. R.; Kim, D. H. "Synthesis of Optically Active 2-Alkyl-3,4-iminobutanoic Acids. b-Amino Acids Containing an Aziridine Heterocycle", J. Org. Chem. 2001, 66, 3696.

Kim, D. H. "Origin of Chiral Pharmacology: Stereochemistry in Metalloprotease Inhibition", Mini Rev. Med.Chem. 2001, 1, 155.

Chung S. J.; Chung, S.; Lee, H. S.; Kim, E.; Oh, K. S.; Choi, H. S.; Kim, K. S.; Kim, Y. J.; Hahn, J. H.; Kim, D. H. "Mechanistic Insight into the Inactivation of Carboxypeptidase A by a-Benzyl-2-oxo-1,3-oxazolidine-4-acetic Acid, a Novel Type of Irreversible Inhibitor for Carboxypeptidase A with No Stereospecificity", J. Org. Chem. 2001, 66, 6462.

Lee, M.; Kim, D. H. "Inhibition of carboxypeptidase A with beta-lactone-bearing phenylalanine. Design, synthesis, and stereochemistry-dependent inhibition mode", Bull. Kor. Chem. Soc. 2001, 22, 1236.

Park, J.; Kim, D. H. "2-Benzyl-3,4-iminobutanoic Acid as Inhibitor of Carboxypeptidase A", Bioorg. Med. Chem. Lett. 2001, 11, 2967.

2000

Kim, D. H.; Lee, S. S. "Origin of Rate-Acceleration in Ester Hydrolysis with Metalloprotease Mimics", Bioorg. Med. Chem. 2000, 8, 647-652.

Lee, M. J.; Kim, D. H. "Hippurylmethylphenylalanine and Hippuryl methyl phenyllactic Acid as Substrates for Carboxypeptidase A.Syntheses, Kinetic Evaluation and Mechanistic Implicationrigin of Chiral Pharmacology: Stereochemistry in Metalloprotease Inhibition", Bioorg. Med. Chem. 2000, 8, 815-823.

Han, M. S.; Ryu, C. H.; Chung, S. J.; Kim, D. H. "A Novel Strategy for Designing Irreversible Inhibitors of Metalloproteases: Acetals as Latent Electrophiles That Interact with Catalytic Nucleophile at the Active Site", Org. Lett. 2000, 20, 3149-3152.

1999

Kim, D. H. "Design of Protease Inhibitors on the Basis of Substrate Stereospecificity ", Biopolymer 1999, 51, 3-8.

Lee, M. J.; Jin, Y. H.; Kim, D. H. "2-Benzyl-2-methylsuccinic Acid as Inhibitor for Carboxypeptidase A. Synthesis and Evaluation", Bioorg. Med. Chem. 1999, 7, 1755-1760.

Kim, D. H.; Jin, Y. H. "First Hydroxamate Inhibitors for Carboxypeptidase A. N-Acyl-N-hydroxy -b-Phenylalanines.", Bioorg. Med. Chem. Lett. 1999, 9, 691-696.

Chin, J.; Lee, S. S.; Lee, Park, S. S.; Kim, D. H. "A metal complex that binds a-amino acids with high and predictable stereospecificity", Nature 1999, 401, 254-257.

Kim, D. H.; Chung, S. M. "Stereochemistry in enzyme inhibition: synthesis and evaluation of enantiomerically pure 2-benzyl-3-formylpropanoic acids as inhibitors of carboxypeptidase A", Tetrahedron: Asymmetry 1999, 10, 3769-3776.

1998

Lee, K. J.; Kim, D. H. "Design of Mechanism-Based Carboxypeptidase A Inactivators on the Basis of the X-ray Crystal Structure and Catalytic Reaction Pathway", Bioorg. Med. Chem. 1998, 6, 1613-1622.

Kim, D. H..; Li, Z. H.; Lee, S. S.; Park, J. I.; Chung, S. J. "A Novel Type of Structurally Simple Nonpeptide Inhibitors for a-Chymotrypsin. Induced-fit Binding of Methyl 2-allyl-3-benzene-propanoate to the S2 Subsite Pocket", Bioorg. Med. Chem. Lett. 1998, 6, 239- 249.

Lee, K. J.; Kim, D. H. "Inhibition of Thermolysin With Nitron-Bearing Substrate Analogs: A New Type of Thermolysin Inhibitors", Bioorg. Med. Chem. Lett. 1998, 8, 323-326.

Lee, K. J.; Kim, D. H. "Detection of Anhydride Intermediate in the Carboxypeptidase A Catalyzed Hydrolysis of a Peptide Substrate by Solid State NMR Spectroscopy and Its Mechanistic Implication", Bioorg. Med. Chem. Lett. 1998, 8, 3379- 3384.

Jin, Y. H.; Kim, D. H. "Inhibition Stereochemistry of Hydroxamate inhibitors for Thermolysin",Bioorg. Med. Chem. Lett. 1998, 8, 3515-3518.

Kim, D. H.; Chung, S. J.; Kim, E. J.; Tian, G. R. "Irreversible Inhibition of Zinc-Containing Protease by Oxazolidinone Derivatives. Novel Inactivation Chemistry ",Bioorg. Med. Chem. Lett. 1998, 8, 859-864.