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[Prof. Seung Hwan Cho] Diborylmethyl Group as a Transformable Building Block for the Diversification of Nitrogen-Containing Molecules

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작성자 최고관리자 댓글 조회 작성일 22-08-09 13:12


Chiwon Hwang†, Yeosan Lee†, Minjae Kim, Younggyu Seo, and Seung Hwan Cho*   The development of new approaches to installing diverse carbon fragments to a nitrogen atom has attracted considerable attention in chemical science. While numerous strategies have been devised to forge C(sp3)–N bonds, one conceptually powerful and straightforward approach is to insert a transformable sp3-carbon unit onto a nitrogen atom for modular diversification. Here we describe the successful synthesis of halo-diborylmethanes and their applications to the preparation of nitrogen-substituted diborylmethanes through their homologative coupling with a variety of nitrogen nucleophiles including biologically relevant molecules. This process exhibits a remarkably broad substrate scope, and the usefulness of the obtained compounds is demonstrated by the modular diversification of the diborylmethyl group to access various nitrogen-containing molecules.   https://doi.org/10.1002/anie.202209079


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