페이지 정보작성자 최고관리자 댓글 조회 작성일 21-06-23 09:35
Highly Stable 1,2-Dicarbonyl Radical Cations Derived from N-Heterocyclic Carbenes
Youngsuk Kim, Jung Eun Byeon, Gu Yoon Jeong, Seoung Su Kim, Hayoung Song, Eunsung Lee*
Stable organic radicals have been of great academic interest not only in the context of fundamental understanding of reactive intermediates but also because of their numerous applications as functional materials. Apart from the early examples of triphenylmethyl and TEMPO derivatives, reports on air- and water-stable organic radicals are scarce, and their development remains a challenge. Herein, we present the design and synthesis of a novel organic radical based on a 1,2-dicarbonyl scaffold supported by N-heterocyclic carbenes (NHCs). The presented radical cations exhibit remarkable stability toward various harsh conditions, such as the presence of reactive chemicals (reductants, oxidants, strong acids, and bases) or high temperatures, by far exceeding the stability of triphenylmethyl and TEMPO radicals. In addition, physiological conditions including aqueous buffer and blood serum are tolerated. The steric and electronic stabilization provided by the two NHC moieties enabled the successful design of the highly stable radical. https://pubs.acs.org/doi/10.1021/jacs.1c00707
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