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ۼ : 17-11-29 17:43
[2017.11] ܹ ȣۿ
-
 ۾ :
ȸ : 87  

װб ܹ ȣۿ ν Ǻο ϴ ϴ ߿ Ͽ, ̸ Ǻο ġ ߿ ο Ͽ

ֱ ȯ , Ȱ ȭ Բ Ǻο δ ȯڰ ް ϰ , 2020⿡ ȯڼ 1 4õ ̸ ǰ ִ. Ǻο ˷⼺ Ǻȯ ѷ ġ ʿ ȯ, ๰ ۿ Ѱ谡 ִ.

  ü 鿪ȣ޿ ߿ ϴ STAT6 ܹ ָ ߴ. STAT6 ϰ ȰȭǸ ˷⼺ ȯ ϴ ι ϰ, ̷ Ǽ Ǻȯ ߻ϴ ˷ ִ. STAT6 Ȱ Ǻο ġḦ , STAT6 پ Ȱ ۿ ȴ.

  ̹ ߱ STAT6 ʹ ޸ STAT6 NCOA1 纸 ܹ ȣۿ ϴ ̴. پ STAT6 ȿ Ͽ ˷⼺ ȯ ϴ ȮϿ. ̿ ġ ۿ Ǽ Ǻο ġ ȴ.

 ̹ ֵ װб ڻ ̿ ʷSTAT6/NCOA1 ܹ ȣۿ ϴ ˷⼺ ȿ Ͽ, ̸ ˷⼺ ȯ ο ġ Ͽ. ߱ ȹ ġμ ߵ Ѵ. ܿ õİ ˷ ȯ ġε Ѵ Ǹ .

  ѱ ߰߿ ޾ Ǿ, 뱸÷Ƿ 翵 ڻ ʰп ӽ ̷. ȭко ְ ̱ȭȸ(Journal of the American Chemical Society) 11 2ڷ ¶ǿ Ǿ.

   

The research group led by Prof. Hyun-Suk Lim at POSTECH has recently developed a new therapeutic strategy for the treatment of inflammatory allergic diseases such as atopic disease and asthma.

 The research team discovered a novel STAT6 inhibitor. STAT6 is a transcription factor that plays a central role in regulating immune signaling pathways. Because overly activated STAT6 is implicated in inflammatory allergic diseases (e.g., asthma and atopic disease), STAT6 signaling has been proposed as a promising therapeutic target. In this study, the research team developed a novel class of STAT6 inhibitors acting by antagonizing the interaction between STAT6 and NCOA1 (a coactivator protein required for STAT6 transcription activity). The team also has demonstrated that this inhibitor effectively suppresses the production of causative factors of atopic dermatitis by disrupting the complex between STAT6 and NCOA1 in vitro and in cells. This study for the first time demonstrated that inhibitors of STAT6/NCOA1 protein-protein interaction can suppress the allergic inflammation reaction and could be a new therapeutic strategy for the treatment of allergic inflammatory diseases including atopic dermatitis. 


 
 

Total 78
ȣ     ۾ ¥ ȸ
78 [2017.11] ܹ ȣۿ 11-29 88
77 [2017.11] Triazenyl Radicals Stabilized by N-Heterocyclic Carbenes 11-21 136
76 [2017.11] Interface-Confined Doubly Anisotropic Oxidation of Two-Dimensional MoS2 11-08 176
75 [2017.11] Structural and Optical Properties of Single- and Few-Layer Magnetic Semiconductor CrPS4 11-01 194
74 [2017.10] Therapeutic gas responsive hydrogel 10-16 165
73 [2017.08] 輺 Light-Induced Fluorescence Modulation of Quantum Dot-Crystal Violet Conjugates: Stochastic Off–On–Off Cycles for Multicolor Patterning and Super-Resolution 08-29 302
72 [2017.07]ȯ Diastereo- and Enantioselective Synthesis of -Aminoboronate Esters by Copper(I)-Catalyzed 1,2-Addition of 1,1-Bis[(pinacolato)boryl]alkanes to Imines 07-20 384
71 [2017.06]ڹ Tattooing Dye as a Green Electrode Material for Lithium Batteries 07-03 375
70 [2017.04]輺 Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window 04-20 662
69 [2017.01]ȯ Chemoselective Coupling of 1,1-Bis[(pinacolato)boryl]alkanes for the Transition-Metal-Free Borylation of Aryl and Vinyl Halides: A Combined Experimental and Theoretical Invesitigation 01-02 1200
68 [2016.11]ڹ 1 Volt-Driven Superfast Polymer Actuators Based on Single Ion Conductors 11-16 1121
67 [2016.09]α Ultrathin and Flat Layer Black Phosphorus Fabricated by Reactive Oxygen and Water Rinse 09-22 1100
66 [2016.08]ö Unique Crystallization of Fullerenes: Fullerene Flowers 08-30 683
65 [2016.08]ö Nanocomb Architecture Design Using Germanium Selenide as High Performance Lithium Storage Material 08-29 966
64 [2016.08]ؿ Visualization and Quantification of MicroRNA in a Single Cell Using Atomic Force Microscopy 08-17 904
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