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ۼ : 17-10-16 11:21
[2017.10] Therapeutic gas responsive hydrogel
 ۾ :
ȸ : 111  

Therapeutic gas responsive hydrogel



Junghong Park, Swapan Pramanick, Dongsik Park, Jiwon Yeo, Jihyun Lee, Haeshin Lee, Won Jong Kim*


ڰ鿪 ȯ ִ ๰ ÷ ϰ ϻȭҿ ִ ̵ Ͽ. ̵ Ƽ ֺ ϻȭҸ ڰ鿪 ̻ Ѵ. Ȱ ٷ ϸ鼭 ÿ ๰ ִ. ̸ ϱ ϻȭҿ ִ ռϿ, ̵ Ǫ 3~5 . ִ ļ ̵ ȿ Ͽ. ̵ ϻȭҰ ƴ ̷ ԵǾ 3̻ ߴ. ̷ ๰ ־ ϸ Ȱ η 鼭 ๰ о ġȿ شȭ Ѵ. ̷ ๰ ÷ ̿Ͽ Ƽ ġϴµ ϰ Ȱ ȴ. 2017 10, м 꽺 ͸ (Advanced Materials) Ǿ, front cover image Ǿ.

 

We report a hydrogel capable of responding to nitric oxide in order to develop a drug delivery platform that can be used for autoimmune diseases. We expected that the hydrogel could selectively inhibit nitric oxide around rheumatoid arthritis to suppress autoimmune adverse events. In addition, it could absorb a large amount of synovial fluid in a highly inflammatory region while simultaneously releasing the drug. For this purpose, a crosslinker capable of reaction with NO was synthesized, and the relative degree of swelling of the hydrogel was increased by 3 to 5 times. The effect of hydrogels was demonstrated through living macrophages. When the hydrogel and NO were encountered, the gap of the polymer network were opened, the mass increased more than three times before the experiment because the water flowed in between them. When the drug is injected into the lesion, the synovial fluid enters the gel and is expected to maximize the therapeutic effect by pushing the drug. It is really expected that this drug delivery platform will be useful for the treatment of diseases such as rheumatoid arthritis. This results of this study were published in the international journal of Advanced Materials in October, 2017 and selected as front cover.


 
 

Total 77
ȣ     ۾ ¥ ȸ
77 [2017.11] Triazenyl Radicals Stabilized by N-Heterocyclic Carbenes 11-21 26
76 [2017.11] Interface-Confined Doubly Anisotropic Oxidation of Two-Dimensional MoS2 11-08 86
75 [2017.11] Structural and Optical Properties of Single- and Few-Layer Magnetic Semiconductor CrPS4 11-01 109
74 [2017.10] Therapeutic gas responsive hydrogel 10-16 112
73 [2017.08] 輺 Light-Induced Fluorescence Modulation of Quantum Dot-Crystal Violet Conjugates: Stochastic Off–On–Off Cycles for Multicolor Patterning and Super-Resolution 08-29 248
72 [2017.07]ȯ Diastereo- and Enantioselective Synthesis of -Aminoboronate Esters by Copper(I)-Catalyzed 1,2-Addition of 1,1-Bis[(pinacolato)boryl]alkanes to Imines 07-20 334
71 [2017.06]ڹ Tattooing Dye as a Green Electrode Material for Lithium Batteries 07-03 325
70 [2017.04]輺 Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window 04-20 608
69 [2017.01]ȯ Chemoselective Coupling of 1,1-Bis[(pinacolato)boryl]alkanes for the Transition-Metal-Free Borylation of Aryl and Vinyl Halides: A Combined Experimental and Theoretical Invesitigation 01-02 1132
68 [2016.11]ڹ 1 Volt-Driven Superfast Polymer Actuators Based on Single Ion Conductors 11-16 1060
67 [2016.09]α Ultrathin and Flat Layer Black Phosphorus Fabricated by Reactive Oxygen and Water Rinse 09-22 1037
66 [2016.08]ö Unique Crystallization of Fullerenes: Fullerene Flowers 08-30 635
65 [2016.08]ö Nanocomb Architecture Design Using Germanium Selenide as High Performance Lithium Storage Material 08-29 921
64 [2016.08]ؿ Visualization and Quantification of MicroRNA in a Single Cell Using Atomic Force Microscopy 08-17 856
63 [2016.06]ȯ Transition-Metal-Free Regioselective Alkylation of Pyridine N-Oxides Using 1,1-Diborylalkanes as Alkylating Reagents 06-29 1082
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