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ۼ : 17-10-16 11:21
[2017.10] Therapeutic gas responsive hydrogel
 ۾ :
ȸ : 373  

Therapeutic gas responsive hydrogel



Junghong Park, Swapan Pramanick, Dongsik Park, Jiwon Yeo, Jihyun Lee, Haeshin Lee, Won Jong Kim*


ڰ鿪 ȯ ִ ๰ ÷ ϰ ϻȭҿ ִ ̵ Ͽ. ̵ Ƽ ֺ ϻȭҸ ڰ鿪 ̻ Ѵ. Ȱ ٷ ϸ鼭 ÿ ๰ ִ. ̸ ϱ ϻȭҿ ִ ռϿ, ̵ Ǫ 3~5 . ִ ļ ̵ ȿ Ͽ. ̵ ϻȭҰ ƴ ̷ ԵǾ 3̻ ߴ. ̷ ๰ ־ ϸ Ȱ η 鼭 ๰ о ġȿ شȭ Ѵ. ̷ ๰ ÷ ̿Ͽ Ƽ ġϴµ ϰ Ȱ ȴ. 2017 10, м 꽺 ͸ (Advanced Materials) Ǿ, front cover image Ǿ.

 

We report a hydrogel capable of responding to nitric oxide in order to develop a drug delivery platform that can be used for autoimmune diseases. We expected that the hydrogel could selectively inhibit nitric oxide around rheumatoid arthritis to suppress autoimmune adverse events. In addition, it could absorb a large amount of synovial fluid in a highly inflammatory region while simultaneously releasing the drug. For this purpose, a crosslinker capable of reaction with NO was synthesized, and the relative degree of swelling of the hydrogel was increased by 3 to 5 times. The effect of hydrogels was demonstrated through living macrophages. When the hydrogel and NO were encountered, the gap of the polymer network were opened, the mass increased more than three times before the experiment because the water flowed in between them. When the drug is injected into the lesion, the synovial fluid enters the gel and is expected to maximize the therapeutic effect by pushing the drug. It is really expected that this drug delivery platform will be useful for the treatment of diseases such as rheumatoid arthritis. This results of this study were published in the international journal of Advanced Materials in October, 2017 and selected as front cover.


 
 

Total 79
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79 [2018.02]ڹ ĸ ̿ ΰ 03-02 284
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74 [2017.10] Therapeutic gas responsive hydrogel 10-16 374
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