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ۼ : 17-04-20 17:04
[2017.04]輺 Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window
 ۾ :
ȸ : 737  



Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window



Sanghwa Jeong, Jaejung Song, Wonseok Lee, Yeon Mi Ryu, Yebin Jung, Sang-Yeob Kim, Kangwook Kim, Seong Cheol Hong, Seung Jae Myung, and Sungjee Kim*



Ҵ ߱ȣ ߰ϸ ܼ ˷ִ Ͽ. Ҵ ǥ ⹰ Ҵ ϴ ̵ ̿, 2ܼ ȣ ϴµ ߴ. ׸ Ҵ ϼ Ǵ ⹰ Ÿ̵ , ҿ ȣ ̴ٰ ó ߱ȣ ̴ Ҵ κ긦 ߴ. ⼭ ̿ 2ܼ ܼ ü Ͼ ̸ ̿ ü ִ ް ִ ̴.
̷ ̱ȭȸ(ACS) ߰ϴ 뷹ͽ(Nano Letters) ȮǾ.


We report an enzyme-activatable NIR-II probe that exhibits FL upon matrix metalloprotease activity in tumor microenvironment. Bright and stable PbS/CdS/ZnS core/shell/shell quantum dots (QDs) were synthesized as a model NIR-II fluorophore, and activatable modulators were attached to exploit photoexcited electron transfer (PET) quenching. The quasi type-II QD band alignment allowed rapid and effective FL modulations with the compact surface ligand modulator that contains methylene blue PET quencher. The modulator was optimized to afford full enzyme accessibility and high activation signal surge upon the enzyme activity. Using a colon cancer mouse model, the probe demonstrated selective FL activation at tumor sites with 3-fold signal enhancement in 10 min. Optical phantom experiments confirmed the advantages of the NIR-II probe over conventional dyes in the first near-infrared region.


 
 

Total 78
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70 [2017.04]輺 Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window 04-20 738
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