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작성일 : 16-01-27 18:52
[16.01월] 김원종교수 연구실 - Synergistic Nanomedicine by Combined Gene and Photothermal therapy
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 글쓴이 : 관리자
조회 : 958  

Synergistic Nanomedicine by Combined Gene and Photothermal therapy

Jinhwan Kim, Jihoon Kim, Cherlhyun Jeong*, Won Jong Kim*

To date, various nanomaterials with the ability for gene delivery or photothermal effect have been developed in the field of biomedicine. The therapeutic potential of these nanomaterials has raised considerable interests in their use in potential next-generation strategies for effective anticancer therapy. In particular, the advancement of novel nanomedicines utilizing both therapeutic strategies of gene delivery and photothermal effect has generated much optimism regarding the imminent development of effective and successful cancer treatments. In this review, we discuss current research progress with regard to combined gene and photothermal therapy. This review focuses on synergistic therapeutic systems combining gene regulation and photothermal ablation as well as logically designed nano-carriers aimed at enhancing the delivery efficiency of therapeutic genes using the photothermal effect. The examples detailed in this review provide insight to further our understanding of combinatorial gene and photothermal therapy, thus paving the way for the design of promising nanomedicines.

다양한 나노물질들이 유전자 전달, 약물 전달, 광역학 치료, 광열치료등과 같은 생의학적 응용에 이용되어 왔다. 이 중 유전자 치료와 광열 치료의 조합은 각각의 치료효과가 가지는 단점을 극복하며 최적화된 나노약물로 이용될 수 있다는 점에서 많은 각광을 받고 있다. 본 연구단에서는 유전자 치료와 광열 치료를 각각 이용해 진보된 치료효과를 보이는 결과 및 광열 자극을 이용해 유전자 치료의 효율을 증대시키는 연구등을 여러 국제 학술지에 발표하였으며, 이를 종합하여 Advanced Drug Delivery Reviews “Therapeutics for Synergistic Therapy” 호에 발간되었다.


 
 

Total 70
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70 [2017.04]김성지교수 연구실 Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window 관리자 04-20 196
69 [2017.01]조승환교수 연구실 Chemoselective Coupling of 1,1-Bis[(pinacolato)boryl]alkanes for the Transition-Metal-Free Borylation of Aryl and Vinyl Halides: A Combined Experimental and Theoretical Invesitigation 관리자 01-02 682
68 [2016.11]박문정교수 연구실 1 Volt-Driven Superfast Polymer Actuators Based on Single Ion Conductors 관리자 11-16 702
67 [2016.09]류순민교수 연구실 Ultrathin and Flat Layer Black Phosphorus Fabricated by Reactive Oxygen and Water Rinse 관리자 09-22 791
66 [2016.08]최희철교수 연구실 Unique Crystallization of Fullerenes: Fullerene Flowers 관리자 08-30 446
65 [2016.08]최희철 교수 연구실 Nanocomb Architecture Design Using Germanium Selenide as High Performance Lithium Storage Material 관리자 08-29 705
64 [2016.08]박준원 교수 연구실 Visualization and Quantification of MicroRNA in a Single Cell Using Atomic Force Microscopy 관리자 08-17 648
63 [2016.06]조승환 교수 연구실 Transition-Metal-Free Regioselective Alkylation of Pyridine N-Oxides Using 1,1-Diborylalkanes as Alkylating Reagents 관리자 06-29 868
62 [2016.05]박준원 교수 연구실 Quantification of Fewer Than Ten Copies of a DNA Biomarker without Amplification or Labeling 관리자 05-16 850
61 [16년03월]김원종교수 연구실-Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery 관리자 03-30 1021
60 [16.01월]조승환교수 연구실-Synthesis of Branched Alkylboronates by Copper-Catalyzed Allylic Substitution Reactions of Allylic Chlorides with 1,1-Diborylalkanes 관리자 01-28 1307
59 [16.01월] 김원종교수 연구실 - Synergistic Nanomedicine by Combined Gene and Photothermal therapy 관리자 01-27 959
58 [15.11월] 임현석 교수 연구실- A chemical inhibitor of the Skp2/p300 interaction that promotes p53-mediated apoptosis 관리자 11-26 1262
57 [15.11월] 김기문교수 연구실- Hydrolytic Transformation of Microporous Metal–Organic Frameworks to Hierarchical Micro- and Mesoporous MOFs 관리자 11-11 1116
56 [15.8월] 김기문교수 연구실- Porphyrin Boxes: Rationally Designed Porous Organic Cages 관리자 09-07 1142
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