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ۼ : 15-06-04 09:31
[15.05]ȱѱ -Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging
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ȸ : 1,178  

Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging

Dokyoung Kim, Hyunsoo Moon, Sung Hoon Baik, Subhankar Singha, Yong Woong Jun, Taejun Wang, Ki Hean Kim, Byung Sun Park, Junyang Jung, Inhee Mook-Jung, and Kyo Han Ahn.

 

 

Fluorescence imaging of tissues offer an essential means for studying biological systems. Autofluorescence becomes a serious issue in tissue imaging under excitation at UV vis wavelengths where biological molecules compete with the fluorophore. To address this critical issue, a novel class of fluorophores that can be excited at 900 nm under two-photon excitation conditions and emits in the red wavelength region (600 nm) has been disclosed. The new -extended dipolar dye system shows several advantageous features including minimal autofluorescence in tissue imaging and pronounced solvent-sensitive emission behavior, compared with a widely used two-photon absorbing dye, acedan. As an important application of the new dye system, one of the dyes was developed into a fluorescent probe for amyloid- plaques, a key biomarker of Alzheimers disease. The probe enabled in vivo imaging of amyloid- plaques in a disease-model mouse, with negligible background signal. The new dye system has great potential for the development of other types of two-photon fluorescent probes and tags for imaging of tissues with minimal autofluorescence.

 

 

ȭ ʼ ˷ ִµ ȭ  ڿܼ ϴ ü 鼭 ü ϴڰ ū εǰִڰ غϱ Ͽ 900 nm ̱ڸ ϴ ο  ü ν 600 nm ̻ ڰ ũ Ͽ Ͽ. ̱ ȭ θ Ǵ Ƽܰ Ҿ ξ ȭ ڰ ν ǿ뼺 Ͽ. ġ ̿ Ŀ ƹз̵ Ÿ ν ũ ͸ ν ȭȸ J. Am. Chem. Soc. 2015 5 7 Ǿ.


 
 

Total 73
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