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ۼ : 14-07-16 18:11
[14.07] _Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinsons disease-associated -synuclein
 ۾ :
ȸ : 1,437  

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinsons disease-associated -synuclein

- Misook Oh, Ji Hoon Lee, Wei Wang, Hui Sun Lee, Christopher Burlak, Wonpil Im, Quyen Q. Hoang, and Hyun-Suk Lim

Many complex diseases are caused by aberrant protein–protein interactions or protein misfolding, which present immense challenges for drug discovery. Here, we present the design, synthesis, and usage of a diverse library of potential pharmacological chaperones that could interfere with undesirable protein–protein interactions and prevent aggregation of misfolded proteins.

ܹ ȣۿ ü ׻ ʼ̸, ܹ ȣۿ , ġ پ ȯ . ̷ ȯ-Ư ܹ ȣۿ žళ ǥ, ܹ ȣۿ ϴ ๰ žళ߿ о߷ ˷ . ܹ ȣۿ ִ ϰ ȿ ߱ ִ ȹ Ͽ. ̷ ׾ ĺ Ų ġ ĺ ߱Ͽ. ̹ ܹ ȣۿ ̻ پ ġ ȯ ġ ߿ . ̱пȸ(PNAS) ¶ Ӻ(7 14) Ǿ, Ư ϷϿ.


 
 

Total 73
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43 [14.07] _Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinsons disease-associated -synuclein 07-16 1438
42 [14.07] _i-motif Driven Au Nanomachines in Programmed siRNA Delivery for Gene-Silencing and Photothermal Ablation. 07-02 1351
41 [14.05]μ -Surface-Specific Deposition of Catalytic Metal Nanocrystals on Hollow Carbon Nanospheres via Galvanic Replacement Reactions of Carbon-Encapsulated MnO Nanoparticles 06-10 1330
40 [14.05] _Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy 05-14 1538
39 [14.03]ϱ -Ultrafast Generation of Fundamental and Multiple-Order Phonon Excitations in Highly Enriched (6,5) Single-Wall Carbon Nanotubes 03-17 1416
38 [14.01] ö -Patternable Large-Scale Molybdenum Disulfide Atomic Layers Grown by Gold-Assisted Chemical Vapor Deposition 01-24 1501
37 [14.1] ⹮ - Hollow Nanotubular Toroidal Polymer Microrings 01-08 1550
36 [13.12] ⹮ - Cucurbit[7]uril: A High-Affinity Host for Encapsulation of Amino Saccharides and Supramolecular Stabilization of Their -Anomers in Wate 01-08 1407
35 [13.10]ö -Vertical Crystallization of C60 Nanowires by Solvent Vapor Annealing Process 10-25 1491
34 [13.10]μ -Postsynthetic Functionalization of a Hollow Silica Nanoreactor with Manganese Oxide-Immobilized Metal Nanocrystals Inside the Cavity 10-25 1278
33 [13.09]ö -Copper-Vapor-Assisted Chemical Vapor Deposition for High-Quality and Metal-Free Single-Layer Graphene 09-11 1261
32 [13.09] -Poly(norepinephrine): Ultrasmooth Material-Independent Surface Chemistry and Nanodepot for Nitric Oxide 09-04 1312
31 [13.07]ڹ -Fast Low Voltage Electroactive Actuators Using Nanostructured Polymer Electrolytes 07-30 1589
30 [13.07] -Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide 07-17 1392
29 [13.07]ڹ -Blue-Emitting Self-Assembled Polymer Electrolytes for Fast, Sensitive, Label-Free Detection of Cu(II) Ions in Aqueous Media 07-08 1201
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