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ۼ : 14-05-14 14:42
[14.05] _Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy
 ۾ :
ȸ : 1,538  



 

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

- Ran Namgung, Yeong Mi Lee, Jihoon Kim, Yuna Jang, Byung-Heon Lee, In-San Kim, Pandian Sokkar, Young Min Rhee, Allan S. Hoffman & Won Jong Kim

In this work, we developed a novel nano-assembled drug-delivery system, formed by multivalent host–guest interactions between a polymer–cyclodextrin conjugate and a polymer–paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery. 

ó ڳ ٰ ŬεƮ ٰ(paclitaxel) host-guest չ ũ ๰ü Ͽ. ü ٰ ڱ ü ſ ϸ ٷ ׾ ž ִ.   ׳ ϼ ๰ Ǵ ̱ ׾ ġȿ ִ.


 
 

Total 73
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42 [14.07] _i-motif Driven Au Nanomachines in Programmed siRNA Delivery for Gene-Silencing and Photothermal Ablation. 07-02 1351
41 [14.05]μ -Surface-Specific Deposition of Catalytic Metal Nanocrystals on Hollow Carbon Nanospheres via Galvanic Replacement Reactions of Carbon-Encapsulated MnO Nanoparticles 06-10 1331
40 [14.05] _Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy 05-14 1539
39 [14.03]ϱ -Ultrafast Generation of Fundamental and Multiple-Order Phonon Excitations in Highly Enriched (6,5) Single-Wall Carbon Nanotubes 03-17 1417
38 [14.01] ö -Patternable Large-Scale Molybdenum Disulfide Atomic Layers Grown by Gold-Assisted Chemical Vapor Deposition 01-24 1501
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35 [13.10]ö -Vertical Crystallization of C60 Nanowires by Solvent Vapor Annealing Process 10-25 1492
34 [13.10]μ -Postsynthetic Functionalization of a Hollow Silica Nanoreactor with Manganese Oxide-Immobilized Metal Nanocrystals Inside the Cavity 10-25 1278
33 [13.09]ö -Copper-Vapor-Assisted Chemical Vapor Deposition for High-Quality and Metal-Free Single-Layer Graphene 09-11 1261
32 [13.09] -Poly(norepinephrine): Ultrasmooth Material-Independent Surface Chemistry and Nanodepot for Nitric Oxide 09-04 1313
31 [13.07]ڹ -Fast Low Voltage Electroactive Actuators Using Nanostructured Polymer Electrolytes 07-30 1589
30 [13.07] -Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide 07-17 1393
29 [13.07]ڹ -Blue-Emitting Self-Assembled Polymer Electrolytes for Fast, Sensitive, Label-Free Detection of Cu(II) Ions in Aqueous Media 07-08 1201
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