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ۼ : 14-05-14 14:42
[14.05] _Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy
 ۾ :
ȸ : 1,684  



 

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

- Ran Namgung, Yeong Mi Lee, Jihoon Kim, Yuna Jang, Byung-Heon Lee, In-San Kim, Pandian Sokkar, Young Min Rhee, Allan S. Hoffman & Won Jong Kim

In this work, we developed a novel nano-assembled drug-delivery system, formed by multivalent host–guest interactions between a polymer–cyclodextrin conjugate and a polymer–paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery. 

ó ڳ ٰ ŬεƮ ٰ(paclitaxel) host-guest չ ũ ๰ü Ͽ. ü ٰ ڱ ü ſ ϸ ٷ ׾ ž ִ.   ׳ ϼ ๰ Ǵ ̱ ׾ ġȿ ִ.


 
 

Total 78
ȣ     ۾ ¥ ȸ
48 [15.04] -N-Heterocyclic Carbene Nitric Oxide Radicals 05-06 1759
47 [15.04]ؿ -Cytosolic targeting factor AKR2A captures chloroplast outer membrane-localized client proteins at the ribosome during translation 04-23 1707
46 [15.02]⹮ -Reversible Morphological Transformation between Polymer Nanocapsules and Thin Films through Dynamic Covalent Self-Assembly 02-09 1467
45 [14.09]ؿ -Reading Single DNA with DNA Polymerase Followed by Atomic Force Microscopy 09-18 1915
44 [14.08]ö _Crystallization-Induced Properties from Morphology-Controlled Organic Crystals 08-21 1689
43 [14.07] _Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinsons disease-associated -synuclein 07-16 1572
42 [14.07] _i-motif Driven Au Nanomachines in Programmed siRNA Delivery for Gene-Silencing and Photothermal Ablation. 07-02 1647
41 [14.05]μ -Surface-Specific Deposition of Catalytic Metal Nanocrystals on Hollow Carbon Nanospheres via Galvanic Replacement Reactions of Carbon-Encapsulated MnO Nanoparticles 06-10 1416
40 [14.05] _Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy 05-14 1685
39 [14.03]ϱ -Ultrafast Generation of Fundamental and Multiple-Order Phonon Excitations in Highly Enriched (6,5) Single-Wall Carbon Nanotubes 03-17 1595
38 [14.01] ö -Patternable Large-Scale Molybdenum Disulfide Atomic Layers Grown by Gold-Assisted Chemical Vapor Deposition 01-24 1631
37 [14.1] ⹮ - Hollow Nanotubular Toroidal Polymer Microrings 01-08 1825
36 [13.12] ⹮ - Cucurbit[7]uril: A High-Affinity Host for Encapsulation of Amino Saccharides and Supramolecular Stabilization of Their -Anomers in Wate 01-08 1707
35 [13.10]ö -Vertical Crystallization of C60 Nanowires by Solvent Vapor Annealing Process 10-25 1567
34 [13.10]μ -Postsynthetic Functionalization of a Hollow Silica Nanoreactor with Manganese Oxide-Immobilized Metal Nanocrystals Inside the Cavity 10-25 1373
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