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ۼ : 13-07-17 09:07
[13.07] -Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide
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ȸ : 1,477  

Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide
Hyunwoo Kim, Duhwan Lee, Jinhwan Kim, Tae-il Kim *, and Won Jong Kim*

In this work, we developed functionalized reduced graphene oxide (PEG-BPEIrGO) as a nanotemplate for photothermally triggered cytosolic drug delivery. PEG-BPEI-rGO/DOX complex was found to escape from endosomes after cellular uptake by photothermally induced endosomal disruption and the proton sponge effect, followed by GSH-induced DOX release into the cytosol. Finally, it was concluded that a greater cancer cell death efficacy was observed in PEG-BPEI-rGO/DOX complex-treated cells with NIR irradiation than those with no irradiation.

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Total 77
ȣ     ۾ ¥ ȸ
47 [15.04]ؿ -Cytosolic targeting factor AKR2A captures chloroplast outer membrane-localized client proteins at the ribosome during translation 04-23 1626
46 [15.02]⹮ -Reversible Morphological Transformation between Polymer Nanocapsules and Thin Films through Dynamic Covalent Self-Assembly 02-09 1377
45 [14.09]ؿ -Reading Single DNA with DNA Polymerase Followed by Atomic Force Microscopy 09-18 1791
44 [14.08]ö _Crystallization-Induced Properties from Morphology-Controlled Organic Crystals 08-21 1615
43 [14.07] _Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinsons disease-associated -synuclein 07-16 1486
42 [14.07] _i-motif Driven Au Nanomachines in Programmed siRNA Delivery for Gene-Silencing and Photothermal Ablation. 07-02 1477
41 [14.05]μ -Surface-Specific Deposition of Catalytic Metal Nanocrystals on Hollow Carbon Nanospheres via Galvanic Replacement Reactions of Carbon-Encapsulated MnO Nanoparticles 06-10 1359
40 [14.05] _Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy 05-14 1616
39 [14.03]ϱ -Ultrafast Generation of Fundamental and Multiple-Order Phonon Excitations in Highly Enriched (6,5) Single-Wall Carbon Nanotubes 03-17 1474
38 [14.01] ö -Patternable Large-Scale Molybdenum Disulfide Atomic Layers Grown by Gold-Assisted Chemical Vapor Deposition 01-24 1566
37 [14.1] ⹮ - Hollow Nanotubular Toroidal Polymer Microrings 01-08 1663
36 [13.12] ⹮ - Cucurbit[7]uril: A High-Affinity Host for Encapsulation of Amino Saccharides and Supramolecular Stabilization of Their -Anomers in Wate 01-08 1557
35 [13.10]ö -Vertical Crystallization of C60 Nanowires by Solvent Vapor Annealing Process 10-25 1515
34 [13.10]μ -Postsynthetic Functionalization of a Hollow Silica Nanoreactor with Manganese Oxide-Immobilized Metal Nanocrystals Inside the Cavity 10-25 1309
33 [13.09]ö -Copper-Vapor-Assisted Chemical Vapor Deposition for High-Quality and Metal-Free Single-Layer Graphene 09-11 1292
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