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ۼ : 13-07-17 09:07
[13.07] -Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide
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ȸ : 1,392  

Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide
Hyunwoo Kim, Duhwan Lee, Jinhwan Kim, Tae-il Kim *, and Won Jong Kim*

In this work, we developed functionalized reduced graphene oxide (PEG-BPEIrGO) as a nanotemplate for photothermally triggered cytosolic drug delivery. PEG-BPEI-rGO/DOX complex was found to escape from endosomes after cellular uptake by photothermally induced endosomal disruption and the proton sponge effect, followed by GSH-induced DOX release into the cytosol. Finally, it was concluded that a greater cancer cell death efficacy was observed in PEG-BPEI-rGO/DOX complex-treated cells with NIR irradiation than those with no irradiation.

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Total 73
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